What is EUMODIC?

EUMODIC will bring together a large consortium of 18 research institutes in 8 European countries who are experts in the field of mouse functional genomics and phenotyping

EUMODIC will undertake a primary phenotype assessment of up to 650 mouse mutant lines.

Mutant lines will be made available from another EU initiative, the EUCOMM (European Conditional Mouse Mutagenesis) project which aims to produce conditional mutations in 20,000 mouse genes.

In addition, a number of these mutant lines will be subject to a more in depth secondary phenotype assessment.

What are the aims of EUMODIC?

The EUMODIC consortium will build on the work in the EUMORPHIA project that delivered a comprehensive database – EMPReSS - of Standard Operating Procedures (SOPs) that can be used to determine the phenotype of a mouse.

EUMODIC has developed a selection of these screens, EMPReSSslim, which is structured for comprehensive, primary, high throughput phenotyping of large numbers of mice

Primary phenotype assessment using EMPReSSslim will be undertaken in four large-scale phenotyping centres at the GSF, Germany ; ICS, France; MRC Harwell, UK and the Sanger Institute, UK .

A distributed network of centres with in depth expertise in a number of phenotyping domains will undertake more complex, secondary phenotyping screens and apply them to a subset of the mice which have shown interesting phenotypes in the primary screen.