EUMODIC brought together a large consortium of 18 research institutes in 8 European countries who are experts in the field of mouse functional genomics and phenotyping

EUMODIC took a primary phenotype assessment of 500 mouse mutant lines. Phenotyping of further mutant lines is being continued by the International Mouse Phenotyping Consortium

Mutant lines were obtained from another EU initiative, the EUCOMM (European Conditional Mouse Mutagenesis) project which aimed to produce conditional mutations in 12,000 mouse genes.

In addition, a number of these mutant lines were subjected to a more in depth secondary phenotype assessment.

What are the aims of EUMODIC?

The EUMODIC consortium built on the work in the EUMORPHIA project that delivered a comprehensive database – EMPReSS – of Standard Operating Procedures (SOPs) that can be used to determine the phenotype of a mouse.

EUMODIC developed a selection of these screens, EMPReSSslim, which is structured for comprehensive, primary, high throughput phenotyping of large numbers of mice

Primary phenotype assessment using EMPReSSslim was undertaken in four large-scale phenotyping centres at the HMGU, Germany; ICS, France; MRC Harwell, UK and the Sanger Institute, UK. This primary phenotyping data will then be made publicly available on EuroPhenome

A distributed network of centres with in depth expertise in a number of phenotyping domains will undertake more complex, secondary phenotyping screens and applied them to a subset of the mice which showed interesting phenotypes in the primary screen.

The EUMODIC project was funded by the European Commission under the Framework 6 Programme contract number LSHG-CT-2006-037188