EUMODIC brought together a large consortium of 18 research institutes in 8 European countries who are experts in the field of mouse functional genomics and phenotyping
EUMODIC took a primary phenotype assessment of 500 mouse mutant lines. Phenotyping of further mutant lines is being continued by the International Mouse Phenotyping Consortium http://www.mousephenotype.org/.
Mutant lines were obtained from another EU initiative, the EUCOMM (European Conditional Mouse Mutagenesis) project which aimed to produce conditional mutations in 12,000 mouse genes.
In addition, a number of these mutant lines were subjected to a more in depth secondary phenotype assessment.
What are the aims of EUMODIC?
The EUMODIC consortium built on the work in the EUMORPHIA project that delivered a comprehensive database – EMPReSS – of Standard Operating Procedures (SOPs) that can be used to determine the phenotype of a mouse.
EUMODIC developed a selection of these screens, EMPReSSslim, which is structured for comprehensive, primary, high throughput phenotyping of large numbers of mice
Primary phenotype assessment using EMPReSSslim was undertaken in four large-scale phenotyping centres at the HMGU, Germany; ICS, France; MRC Harwell, UK and the Sanger Institute, UK. This primary phenotyping data will then be made publicly available on EuroPhenome http://www.europhenome.org/
A distributed network of centres with in depth expertise in a number of phenotyping domains will undertake more complex, secondary phenotyping screens and applied them to a subset of the mice which showed interesting phenotypes in the primary screen.
The EUMODIC project was funded by the European Commission under the Framework 6 Programme contract number LSHG-CT-2006-037188